A JAMA Network Open research paper published today (May 26, 2021) by Doctorpedia contributor Henry P. Barham, MD traces an association between the bitter taste receptor phenotype and clinical outcomes among patients with COVID-19 confirmed that a simple home taste test can be a gamechanger in predicting the duration and symptom severity of the virus.
Left: Doctorpedia Founding Medical Partner Dr. Sanjay Juneja, Right: Doctorpedia provider Dr. Henry P. Barham. Image Credit: Doctorpedia
Speaking exclusively to Doctorpedia, Dr. explained. Henry P. Barham that the study suggested that T2R38 receptor allelic variants are related to the innate resistance response of SARS-CoV-2 participants. The phenotype of T2R is associated with the clinical course of patients after SARS-CoV-2 infection. Non-tasters were more easily hospitalized and experienced more severe and long-lasting symptoms with SARS-CoV-2 than the other 2 groups, suggesting improved protection of natural resistance against SARS-CoV- 2.
Doctorpedia Founding Medical Partner Dr. Sanjay Juneja, who made an exclusive interview with Dr. Barham to find out about the implications of having these scientific findings for COVID -19 diagnosis, commented: “The taste receptors in your mouth – especially bitterness – if you’re the so -called supertaster, […] it can really affect how well viruses clear especially people who taste bitterness actually have a much higher clearance rate to prevent the entry of that virus
The data in this study show that this test can help predict the duration and severity of symptoms. Meaning: yes, if you have a new strain of this Coronavirus or it mutates, or you have another new novel virus-it should continue to be true because it is part of your innate strength and studied- we have it with other viruses, not just COVID […] However I would argue that this is actually a good way to help settle the benefit where people can receive vaccinations, especially in countries where resources are limited. ”
Henry P. Barham, MD, Doctorpedia contributor
The study suggested that bitter taste receptors have been shown to play an important role in innate resistance against high respiratory tract stimuli, and that the different types of receptors explain the magnitude of such natural resistance. . These results may explain why some seemingly healthy young people experience more severe symptoms than others and why treatments including hydroxychloroquine show promise, as it activates Tas2R. receptor.
In this simple taste test, Dr. Barham and his group separated the study participants into three groups: Super-Tasters, Tasters, and Non-Tasters. Dr. shared. Barham shared the results of this exclusive interview with Doctorpedia: “Of those in need of hospitalization, 85% are not tasters, 0% are supertasters, 15% are in the middle group. [tasters.] Now the interesting point there is that in the 15% who need hospitalization (which is in the middle group), the youngest is 69. And the average age is 74. That’s a nakedness of the receptors, meaning they’re in middle group, but as you get older, they get tired and you start to progress towards the non-taster group. “
In the study cohort of 1935 adults, 266 tested positive for SARS- CoV-2 and those who experienced short-lived levels of bitter taste or no bitter taste (non-tasters) were more likely to test positive for SARS- CoV-2, to be hospitalized, and to be symptomatic for a longer period of time. In contrast, those who experienced a more intense bitter taste (supertasters) represented 5.6% of patients infected with SARS-CoV-2, suggesting that the protection of the innate immune system was improved.
The study also found that taste expression was strongly connected to the duration of symptoms. On average, Super-Tasters experienced 5 days of symptoms, Tasters experienced 13.5 days of symptoms, and Non-Tasters experienced 23.7 days of symptoms. The P-value is the time when the outcomes occur at random, with anything not less than 0.05 statistically significant. The P-value in this study was as short as possible: 0.001 (listed as 0.01).
According to Dr. Barham, this taste test is inexpensive, measurable, and accurate to help people gain a better understanding of their potential risk of complications from COVID-19 and other diseases and variety. . “We really tried a test that was more accurate, to the point of about 94.2% accuracy in predicting genotype.”
Supertasters & COVID-19 Heals: Talking to Drs. Henry Barham
Video Credit: Doctorpedia
Please refer to the journal:
Barham, HP, and so on. (2021) Association Between Bitter Taste Receptor Phenotype and Clinical Outcomes Among Patients With COVID-19. JAMA Network opened. doi.org/10.1001/jamanetworkopen.2021.11410.