High vitamin D levels may be unprotected against COVID-19, study suggests


TORONTO-A new Canadian study suggests that taking vitamin D supplements is not protective against COVID-19.

while low vitamin D levels have been linked at an even higher risk of infection and serious illness, a new study conducted by researchers from McGill University in Montreal reports that there is no genetic evidence that the supplement acts as a protective measure against in the coronavirus.

“Vitamin D supplementation as a public health approach to improve outcome was not supported in this study. More importantly, our findings suggest that investment in other therapeutic or preventative avenues should be a priority for COVID. -19 randomized clinical trials, “the study authors wrote.

The findings were published on Tuesday at reviewed in the peer journal PLOS Medicine.

Consistent with the study, the researchers conducted a randomized Mendelian analysis using different genetic strengths associated with increased vitamin D levels to examine the association between supplementation and sensitivity and severity of COVID-19.

The researchers looked at different types of 4,134 individuals with COVID-19, and 1,284,876 without the disease from 11 countries.

According to the researchers in a press release that they wanted to determine whether a genetic predisposition for excessively elevated vitamin D levels resulted in less severe disease outcomes in COVID-19 patients.

The study found “no evidence for an association between predicted genetic vitamin D levels and sensitivity to COVID-19, hospitalization, or severe illness.”

The researchers said the findings suggest that increasing vitamin D levels by taking supplements may not improve the effects of COVID-19 in the majority of the population.

However, the researchers said their research had “many significant limitations,” the more important that the study did not consider those with vitamin D deficiency. Thus, the researchers said it remains possible COVID-19 patients who are “truly deficient” in vitamin D may benefit from the supplement.

Similarly, the researchers examined differences that differed from individuals of European descent. The study said that future research should look at the relationship of vitamin D and COVID-19 outcomes in other populations.

Taking vitamin D to help protect against severe COVID-19 infection has been of interest to public health experts, but the researchers said the subject’s previous data were based on observational studies with limited evidence. .

Dr. Guillaume Butler-Laporte, co-lead author of the study, said most previous studies are difficult to interpret, because they do not match the known risk factors of severe COVID-19, including age and absence old medical condition, which is also predicted by low vitamin D.

“Consequently, the best way to answer the question of the effect of vitamin D can be through repeated tests, but they are very complicated and very useful, and will take a long time during a pandemic,” he explains. he in the press release.

By using a Mendelian randomization, Butler-Laporte said the researchers reduced potential bias from known risk factors, and provided a much clearer link between vitamin D and COVID-19.

“Previously Mendelian randomization consistently predicted the results of multiple, expensive, and timely vitamin D testing. Here, this approach did not present clear evidence that vitamin D supplementation had a significant effect on consequence of COVID-19, “Butler-Laporte said. .





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