Among patients with coronavirus 2019 (COVID-19) who experienced abdominal pain and diarrhea, there was a significant likelihood that Helicobacter pylori (H pylori) infection, according to the results of a study published in Journal of Pediatric Gastroenterology and Nutrition.1
It is now known that acute acute respiratory syndrome coronavirus-2 (SARS-CoV-2), binds to angiotensin-converting enzyme-2 (ACE-2) receptors.2 These receptors are particularly expressed in the intestine, suggesting that SARS-CoV-2 infection may lead to gastrointestinal symptoms in patients with COVID-19.
As in H pylori increases ACE-2 receptor expression in the gastrointestinal tract, a group of researchers in Turkey conducted an investigation from June 1, 2020, to July 20, 2020 to determine the effects of H pylori on the clinical presentation and course of COVID-19 infections.1
COVID-19 positive patients, confirmed by polymerase chain reaction, were included in the analysis. Bank samples were collected and the presence of H pylori determined by antigen testing tests.
A total of 108 patients (mean age, 49.54 years) were included in the analysis: 77 patients tested negative for H pylori infection and 31 patients were positive. Compared to patients who tested negative, patients with H pylori infections are significantly more frequent abdominal pain (P = .007) and distraction (P = .006). However, COVID-19 severity, disease outcome, and number of hospitalized days were not significantly related. H pylori infections
Investigators reported that the association between H pylori infection and abdominal pain and diarrhea in patients with COVID-19 are mediated by ACE-2 receptors. “[T]here is an urgent need for studies examining the availability of H pylori and the expression of ACE-2 receptors in the lungs and in the upper respiratory system, ”the investigators said.1
- Balamtekin N, Artuk C, Arslan M, Gulsen M. The effect of Helicobacter pylori in the presentation and clinical course of coronavirus disease 2019 infection. JPGN. 2021; 72 (4): 511-513. doi: 10.1097 / MPG.0000000000003005
- Lan J, Ge J, Yu J, et al. The structure of the SARS-CoV-2 spike receptor-binding domain bound to the ACE2 receptor. Nature. 2020; 581 (7807): 215-220. duha. 10.1038 / s41586-020-2180-5
This article originally appeared Gastroenterology Advisor